Keeping weight off after taking weight loss meds makes your success truly lasting and life-changing. But it's not easy. There will be obstacles along the way—like holiday meals.
Dr. Holly Wyatt and Dr. Jim Hill—two of the world’s leading experts on long-term weight management—have developed a 10-week transition plan for stopping weight loss meds in the
forthcoming book, Losing the Weight Loss Meds: A 10-Week Playbook for Stopping GLP-1 Medications Without Regaining the Weight (December 16th).
“Maintaining your new weight requires preparation and focus,” says Wyatt and Hill. “It requires a strategy and skills you did not need during weight loss. You can’t simply stop the medication and expect the weight to stay off; unfortunately, that approach usually leads to weight regain. Research shows that most people who discontinue weight loss medication regain a substantial portion of the weight they lost. In one clinical trial, participants regained about two-thirds (66 percent) of their lost weight within a year, with some regaining even more in less time. If you stop the weight loss medication, your weight will eventually rise again too—unless you take other steps to prevent it.”
DR. JIM HILL is a Professor in the Department of Nutrition Sciences at the UAB School of Health Professions and one of the world’s leading experts in obesity. For over 40 years, he has conducted research on the development, health consequences, prevention, and treatment of obesity, publishing more than 700 peer-reviewed papers, reviews, and book chapters. Continuously funded by the NIH since 1981, he currently serves as director and principal investigator of the UAB Nutrition Obesity Research Center (NORC) and previously led the Colorado NORC and the University of Colorado Anschutz Health and Wellness Center.
Dr. Hill co-founded the National Weight Control Registry (NWCR), the premier source of data on long-term weight loss maintenance, and recently co-founded the International Weight Control Registry (IWCR) to study factors affecting obesity treatment success across populations. He has served as an investigator in the Diabetes Prevention Program (DPP) and site PI for the Look AHEAD study, and he now leads UAB initiatives in precision nutrition, investigating why individuals respond differently to dietary interventions.
He is the author of two popular weight management books, The Step Diet Book and The State of Slim, and has developed multiple behavioral weight loss programs. He also co-founded America On the Move, a nonprofit promoting sustainable lifestyle adjustments.
Dr. Hill was elected to the National Academy of Medicine in 2018, and has served as president of both The Obesity Society and The American Society for Nutrition. His current research continues to focus on lifestyle factors that influence obesity and long-term health.
DR. HOLLY WYATT is a physician, endocrinologist, coach, and nationally recognized leader in weight loss and long-term weight management. With more than 25 years of clinical and research experience, she has helped thousands of people not only lose significant amounts of weight but also maintain their success and transform their overall health. Known to millions as the medical doctor on ABC’s hit show Extreme Weight Loss, she brings science to life by guiding individuals through dramatic, real-world transformations.
Her research has followed over 10,000 participants in the National Weight Control Registry to uncover what separates short-term results from lasting success. She is the coauthor of the bestselling book State of Slim and creator of the SOS programs, which provide practical, science-based strategies to reset metabolism, manage appetite, and build habits that endure.
As an endocrinologist, Dr. Wyatt combines expertise in physiology with a deep understanding of behavior, uniquely bridging the gap between how the body works and how people live. She is known for her ability to get inside people’s heads and shift the way they think about food, health, and themselves. By connecting hormonal and metabolic science with mindset and motivation, she helps people break limiting beliefs, strengthen resilience, and achieve transformation that lasts. Whether through clinical practice, public programs, media appearances, or one-on-one coaching, her work empowers people to move beyond surface-level solutions and create sustainable health and true lifestyle change.
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Dr. Wyatt: @drhollywyatt
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Dr. Wyatt: https://linkedin.com/in/holly-
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